![]() Homoeopathic preparations of Symphytum officinale of different potencies (MT, 3C, 6C, 12C, 30C) were commercially procured from HAPCO, Kolkata, India. Section snippets Homoeopathic medicinal preparations of Symphytum officinale Osteogenic differentiation has been evaluated by expression of the markers of osteogenesis. mother tincture (MT), 3C, 6C, 12C and 30C were separately dissolved in basic osteogenic differentiation media (1% v/v), to induce osteogenic differentiation in cultured MSCs over 2 weeks, using appropriate controls. Different homoeopathic potencies of Symphytum officinale viz. In this in vitro study, the potential of Symphytum officinale to induce osteogenic differentiation in human bone marrow derived MSCs has been evaluated. ![]() Thus, other safe and efficacious alternatives with osteogenic potential need to be investigated. However, most of these agents are associated with complications like donor site morbidity, excessive blood loss, immunological reactions, limited efficacy or prohibitively high costs. MSCs along with other orthobiological agents like recombinant proteins (Parathormone, BMP), demineralized bone matrix, autologous or allogenic bone grafts, platelet rich plasma and calcium salts, form part of the armamentarium that help in healing of complicated fractures and fracture non-union by different mechanisms (Roberts and Rosenbaum, 2012). These multipotent stem cells are recommended to treat bone fractures that are difficult to heal (Shao et al., 2015). a bone fracture) and differentiate into osteoblasts (Fakhry et al., 2013). Mesenchymal stem cells (MSCs) help in regenerating and repair of bones by their ability to migrate to the site of bone injury (eg. However, no studies have elucidated the mechanism of its orthobiological properties. Homoeopathic medicines derived from Symphytum officinale have been found to be beneficial in healing of bone fractures (Tsintzas and Vithoulkas, 2016 Sakakura et al., 2008 Spin-Neto et al., 2010). ![]() Homoeopathy is an acknowledged alternate system of medicine and its medicines have been substantiated by several clinical trials (Jonas et al., 2001). Symphytum officinale is recommended for consolidation of bone fractures and to accelerate bone mineralization (Grube et al., 2007). (Boraginaceae), commonly known as Comfrey, is a medicinal plant and has been reported to have properties to heal blunt injuries, bruises, fractures, dislocated joints, damaged muscles and tendons, heal ulcers, etc. ![]()
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